BioVie Inc recently reported some unusual results from a clinical trial for Alzheimer’s.
They report some mildly encouraging cognitive improvements, but it’s only 3 months into the trial and there’s no placebo group, so it’s easy to imagine they’re just seeing a placebo effect (Annovis’ results show a clear placebo effect, presumably influencing the measurement rather than the actual health).
What interested me is this:
Reduces Horvath DNA Methylation SkinBlood Clock by 3.3 years after 3 months of treatment.
Book review: True Age: Cutting-Edge Research to Help Turn Back the Clock, by Morgan Levine.
Another year, another book on aging. This one comes close to saying important things about how to slow down aging, then chickens out just before reaching the finish line.
There’s a new clinical trial result showing that Bredesen’s approach is able to at least partially cure common forms of Alzheimer-like dementia. (Press release here). It has not received as much attention as it deserves.
The 9 month study seemed a bit less impressive than what I’d hoped for, but the outcomes still support the claim that common forms of dementia are partly curable.
Out of 25 patients, 21 or 19 improved their cognition compared to the start of the trial, depending on which measure I look at, and 2 or 3 declined.
Side effects included occasional improvements in hypertension and diabetes, enough to allow patients to stop taking medications for those conditions.
Book review: Ageless: The New Science of Getting Older Without Getting Old, by Andrew Steele.
The latest book on aging is a bit more ambitious than the previous two that I reviewed, but still rather modest compared to Aubrey de Grey’s book that heralded the start of serious attempts at fighting aging.
Ageless is relatively balanced, well-organized, and comprehensive.
Book review: The End of Alzheimer’s Program, by Dale Bredesen.
This sequel to The End of Alzheimer’s is an attempt at a complete guide to a healthy lifestyle.
Alas, science is still too primitive to enable an impressive version of that. So what we end up with is this guide that would overwhelm anyone who tries to follow it thoroughly, while still lacking the kind of evidence that would convince a skeptic.
Books by serious researchers on how to defeat aging are now coming out almost as fast as I have time to read them.
This one mostly aims to enable us live in good health to 115, preferably via a few simple pills.
Book review: Lifespan: Why We Age – and Why We Don’t Have To, by David A. Sinclair.
A decade ago, the belief that aging could be cured was just barely starting to get attention from mainstream science, and the main arguments for a cure came from people with somewhat marginal formal credentials.
Now we have a book by an author who’s a co-chief editor of the scientific journal Aging. He’s the cofounder of 14 biotech companies (i.e. probably more than he’s had enough time to work for full time, so I’m guessing some companies are listing him as a cofounder more for prestige than for full-time work). He’s even respected enough by some supplement companies that they use his name, even after he sends them cease and desist letters.
I’m glad that Sinclair published a book that says aging can be cured, since there’s still a shortage of eminent scientists who are willing to take that position.
I’ve mentioned Blue Zones approvingly several times on this blog (here, here, and here).
Alas, there are reasons to doubt that they’re unusually healthy. The paper Supercentenarians and the oldest-old are concentrated into regions with no birth certificates and short lifespans makes a decent case that they’re mostly just areas where ages have been overstated. There are some relatively unhelpful arguments about who’s right on Andrew Gelman’s blog and on Bluezones.com.
As a consequence, I’m slightly decreasing my opinion of some foods that I was encouraged to eat by the Blue Zone memes: whole grains, beans, olive oil, and sweet potatoes. Sweet potatoes still seem likely to be quite healthy compared to the average American food, but I’m now uncertain whether they’re better or worse than the average paleo food (I previously considered them one of the best foods available). The rest of those foods seem no worse than the average American food, but I’m less optimistic about the safety of the average American food than I previously was.
I’ve also become less confident in the safety of a diet with less than 10% of calories from protein (Blue Zone Okinawans in 1949 got 9% of calories from protein), but I’d already decided not to pursue a low protein diet.
I’ve slightly decreased my opinion of Steven Gundry and Valter Longo
H/T William Eden.
Book review: The Longevity Diet: Discover the New Science Behind Stem Cell Activation and Regeneration to Slow Aging, Fight Disease, and Optimize Weight, by Valter Longo.
Longo is a moderately competent researcher whose ideas about nutrition and fasting are mostly heading in the right general direction, but many of his details look suspicious.
He convinced me to become more serious about occasional, longer fasts, but I probably won’t use his products.
Book review: Tripping over the Truth: the Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure, by Travis Christofferson.
This book is mostly a history of cancer research, focusing on competing grand theories, and the treatments suggested by the author’s preferred theory. That’s a simple theory where the prime cause of cancer is a switch to fermentation (known as the metabolic theory, or the Warburg hypothesis).
He describes in detail two promising treatments that were inspired by this theory: a drug based on 3-bromopyruvate (3BP), and a ketogenic diet.