aging

All posts tagged aging

Super Agers

Posted by Peter on June 26, 2025
Posted in: Book Reviews, Health. Tagged: , . 1 comment

Book review: Super Agers: An Evidence-Based Approach to Longevity, by Eric Topol.

I was somewhat disappointed, partly because the title misled me.

The book is broad and shallow, as if he’s trying to show off how many topics he’s familiar with. Too much of the book consists of long lists of research that Topol finds interesting, but for which I see little connection with aging. He usually doesn’t say enough about the research for me to figure out why I should consider it promising.

He mostly seems to be saying that the number of new research ideas ought to impress us. I care more about the quality of the most promising research than about the quantity of research.

The book is mostly correct and up-to-date, but I’m unclear what kind of reader would get much out of it.

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The Ageless Brain

Posted by Peter on May 1, 2025
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Book review: The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime, by Dale E. Bredesen.

As expected, The Ageless Brain repeats a good deal of information from Bredesen’s prior groundbreaking books about Alzheimer’s. Maybe 10% of the book seemed like ideas that I hadn’t seen elsewhere.

This time, he’s focused a bit more on cognitive decline in people who are young enough to not be at much risk yet for full-fledged Alzheimer’s. But that doesn’t create much of a difference in his advice for brain health.

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Notes from the TRIIM-X Clinical Trial

Posted by Peter on March 18, 2025
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I participated in the TRIIM-X trial, a phase 2 test by Intervene Immune, intended to regrow the thymus. Regrowing the thymus likely delays age-related declines in health.

I’m also an investor in Intervene Immune.

Here’s a video presentation of some results of the trial. It confirms the moderately impressive evidence from the original TRIIM trial.

The main ingredients of the treatment are human growth hormone, metformin, and DHEA.

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The Cancer Resolution?

Posted by Peter on July 23, 2024
Posted in: Book Reviews, Health, Science and Technology. Tagged: . 3 comments

Book review: The Cancer Resolution?: Cancer reinterpreted through another lens, by Mark Lintern.

In the grand tradition of outsiders overturning scientific paradigms, this book proposes a bold new theory: cancer isn’t a cellular malfunction, but a fungal invasion.

Lintern spends too many pages railing against the medical establishment, which feels more like ax-grinding than science. I mostly agreed with his conclusions here, but mostly for somewhat different reasons than the ones he provides.

If you can push through this preamble, you’ll find a treasure trove of scientific intrigue.

Lintern’s central claim is that fungal infections, not genetic mutations, are the primary cause of cancer. He dubs this the “Cell Suppression theory,” painting a picture of fungi as cellular puppet masters, manipulating our cells for their own nefarious ends. This part sounds much more like classical science, backed by hundreds of quotes from peer-reviewed literature.

Those quotes provide extensive evidence that Lintern’s theory predicts dozens of cancer features better than do the established theories.

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Outlive

Posted by Peter on September 13, 2023
Posted in: Book Reviews, Health. Tagged: , , . 1 comment

Book review: Outlive: The Science and Art of Longevity, by Peter Attia.

This year’s book on aging focuses mostly on healthspan rather than lifespan, in an effort to combat the tendency of people in the developed world to have a wasted decade around age 80.

Attia calls his approach Medicine 3.0. He wants people to pay a lot more attention to their lifestyle starting a couple of decades before problems such as diabetes and Alzheimer’s create obvious impacts.

He complains about Medicine 2.0 (i.e. mainstream medicine) treating disease as a binary phenomenon. There’s lots of evidence suggesting that age-related diseases develop slowly over periods of more than a decade.

He’s not aiming to cure aging. He aims to enjoy life until age 100 or 120.

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BioVie

Posted by Peter on December 21, 2022
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BioVie Inc recently reported some unusual results from a clinical trial for Alzheimer’s.

They report some mildly encouraging cognitive improvements, but it’s only 3 months into the trial and there’s no placebo group, so it’s easy to imagine they’re just seeing a placebo effect (Annovis’ results show a clear placebo effect, presumably influencing the measurement rather than the actual health).

What interested me is this:

Reduces Horvath DNA Methylation SkinBlood Clock by 3.3 years after 3 months of treatment.

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New Dementia Trial Results

Posted by Peter on July 1, 2021
Posted in: Health. Tagged: , .

There’s a new clinical trial result showing that Bredesen’s approach is able to at least partially cure common forms of Alzheimer-like dementia. (Press release here). It has not received as much attention as it deserves.

The 9 month study seemed a bit less impressive than what I’d hoped for, but the outcomes still support the claim that common forms of dementia are partly curable.

Out of 25 patients, 21 or 19 improved their cognition compared to the start of the trial, depending on which measure I look at, and 2 or 3 declined.

Side effects included occasional improvements in hypertension and diabetes, enough to allow patients to stop taking medications for those conditions.

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