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Anti-Paleo Diet

Soylent is an almost pure chemical diet, whose most natural looking ingredients are olive oil and whey protein. It provides the FDA recommended nutrients from mostly purified sources of the individual nutrients. The creator claims to have experienced improved health after adopting it (after previously eating something slightly better than a typical US diet).

This seems like a very effective way to minimize the poisons in our diet.

It’s also cheaper than most diets (he claims less than $2/day, but that seems questionable). He claims it tastes good, although eating the same thing day after day would seem a bit monotonous.

FDA recommendations are known to be suboptimal – too little vitamin D, too much calcium.

He seems confused about the fiber requirements, and is a bit reckless about his omega-6/omega-3 ratio. But these are easily improved.

He almost certainly misses some important nutrients that haven’t yet been identified, but that can be partly compensated for by adding a few low-risk foods such as salmon, seaweed, spinach, and sweet potatoes (the four S’s?).

I’m giving some thought to replacing 25-50% of my calories with something along these lines.

Book review: Error and the Growth of Experimental Knowledge by Deborah Mayo.

This book provides a fairly thoughtful theory of how scientists work, drawing on
Popper and Kuhn while improving on them. It also tries to describe a quasi-frequentist philosophy (called Error Statistics, abbreviated as ES) which poses a more serious challenge to the Bayesian Way than I’d seen before.

Mayo’s attacks on Bayesians are focused more on subjective Bayesians than objective Bayesians, and they show some real problems with the subjectivists willingness to treat arbitrary priors as valid. The criticisms that apply to objective Bayesians (such as E.T. Jaynes) helped me understand why frequentism is taken seriously, but didn’t convince me to change my view that the Bayesian interpretation is more rigorous than the alternatives.

Mayo shows that much of the disagreement stems from differing goals. ES is designed for scientists whose main job is generating better evidence via new experiments. ES uses statistics for generating severe tests of hypotheses. Bayesians take evidence as a given and don’t think experiments deserve special status within probability theory.

The most important difference between these two philosophies is how they treat experiments with “stopping rules” (e.g. tossing a coin until it produces a pre-specified pattern instead of doing a pre-specified number of tosses). Each philosophy tells us to analyze the results in ways that seem bizarre to people who only understand the other philosophy. This subject is sufficiently confusing that I’ll write a separate post about it after reading other discussions of it.

She constructs a superficially serious disagreement where Bayesians say that evidence increases the probability of a hypothesis while ES says the evidence provides no support for the (Gellerized) hypothesis. Objective Bayesians seem to handle this via priors which reflect the use of old evidence. Marcus Hutter has a description of a general solution in his paper On Universal Prediction and Bayesian Confirmation, but I’m concerned that Bayesians may be more prone to mistakes in implementing such an approach than people who use ES.

Mayo occasionally dismisses the Bayesian Way as wrong due to what look to me like differing uses of concepts such as evidence. The Bayesian notion of very weak evidence seems wrong given her assumption that concept scientific evidence is the “right” concept. This kind of confusion makes me wish Bayesians had invented a different word for the non-prior information that gets fed into Bayes Theorem.

One interesting and apparently valid criticism Mayo makes is that Bayesians treat the evidence that they feed into Bayes Theorem as if it had a probability of one, contrary to the usual Bayesian mantra that all data have a probability and the use of zero or one as a probability is suspect. This is clearly just an approximation for ease of use. Does it cause problems in practice? I haven’t seen a good answer to this.

Mayo claims that ES can apportion blame for an anomalous test result (does it disprove the hypothesis? or did an instrument malfunction?) without dealing with prior probabilities. For example, in the classic 1919 eclipse test of relativity, supporters of Newton’s theory agreed with supporters of relativity about which data to accept and which to reject, whereas Bayesians would have disagreed about the probabilities to assign to the evidence. If I understand her correctly, this also means that if the data had shown light being deflected at a 90 degree angle to what both theories predict, ES scientists wouldn’t look any harder for instrument malfunctions.

Mayo complains that when different experimenters reach different conclusions (due to differing experimental results) “Lindley says all the information resides in an agent’s posterior probability”. This may be true in the unrealistic case where each one perfectly incorporates all relevant evidence into their priors. But a much better Bayesian way to handle differing experimental results is to find all the information created by experiments in the likelihood ratios that they produce.

Many of the disagreements could be resolved by observing which approach to statistics produced better results. The best Mayo can do seems to be when she mentions an obscure claim by Pierce that Bayesian methods had a consistently poor track record in (19th century?) archaeology. I’m disappointed that I haven’t seen a good comparison of more recent uses of the competing approaches.

Talking20

Talking20 is an ambitious startup attempting to make a wide variety of blood tests available at the surprisingly cheap price of $2 per test. Getting the drop of blood needed will still be a pain, but doing it at home and mailing in a postcard will simplify the process a lot.

If this succeeds it would dramatically increase our knowledge of things such as our cholesterol levels.

But I get the impression that they are being rather optimistic about how quickly they can get enough sales volume to make money.

Their attempt to use Indiegogo doesn’t appear to be as appropriate to their needs as seeking angel or VC investment would be.

I’m also concerned that the institutions they would compete with will try to get them regulated in ways that would drastically increase their costs.

I’m somewhat tempted to order something from them via Indiegogo, but I’m not confident in their ability to deliver.

Book review: How to Measure Anything, by Douglas Hubbard.

I procrastinated about reading this book because it appeared to be only relevant to a narrow type of business problem. But it is much more ambitious, and aims to convince us that anything that matters can be measured. It should be a good antidote to people who give up on measuring important values on grounds such as it’s too hard or too subjective (i.e. it teaches people to do Fermi estimates).

A key part of this is to use a sensible definition of the word measurement:

A quantitatively expressed reduction of uncertainty based on one or more observations

.

He urges us to focus on figuring out what observations are most valuable, because there are large variations in the value of different pieces of information. If we focus on valuable observations, the first few observations are much more valuable than subsequent ones.

He emphasizes the importance of calibration training which, in addition to combating overconfidence, makes it hard for people to claim they don’t know how to assign numbers to possible observations.

He succeeds in convincing me that anything that matters to a business can be measured. There are a few goals for which his approach doesn’t seem useful (e.g. going to heaven), but they’re rarer than our intuition tells us. Even vague-sounding concepts such as customer satisfaction can either be observed (possible with large errors) via customer behavior or surveys, or they don’t matter.

It will help me avoid the temptation of making Quantified-Self types measurements to show off how good I am at quantifying things, and focus instead on being proud to get valuable information out of a minimal number of observations.

At a recent LessWrong meetup, someone described his GTD system with the metaphor automated self, to emphasize that the things he offloads from his mind into the GTD system help him act more robotic. I like the idea of automating some of my actions so that I can further separate planning and execution. The term automated self is a good way to remember that goal, and should be used more widely than it is. Plus I like to distinguish myself from those who attach negative connotations to “robot-like”.

Book review: Food and Western Disease: Health and nutrition from an evolutionary perspective, by Staffan Lindeberg.

This book provides evidence that many causes of death in developed nations are due to a lifestyle that is different from hunter-gatherer lifestyles.

His studies of existing hunter-gatherer societies show moderately good evidence that cardiovascular disease is rare, that aging doesn’t cause significant dementia, and shows weaker evidence of less cancer.

He has some vaguely plausible reasons for focusing on diet as the main lifestyle difference. I’m disappointed that he doesn’t mention intermittent fasting as a factor worth investigating (is it obvious from his experience that some hunter-gatherer societies don’t do this?).

He uses this evidence to advocate a mostly paleo diet, although with less fat than is often associated with that label.

Much of the book is devoted to surveying the evidence about other proposed dietary improvements, mostly concluding they don’t do much (or in the case of calorie restriction, might work by causing a more paleo-like diet).

I don’t have a lot of confidence in his ability to interpret the evidence.

He gives the impression that Omega-3 consumption has little effect on health, citing papers such as this review, whose abstract includes:

showed no strong evidence of reduced risk of total mortality (relative risk 0.87, 95% confidence interval 0.73 to 1.03)

I’d call that evidence for a moderately important benefit of Omega-3, and I consider it strong evidence in comparison to typical dietary studies, although it’s weak compared to the evidence that other scientific fields aim for.

One response from nutrition experts says:

The null conclusion of the Cochrane report rests entirely upon inclusion of one trial, DART 2.

A quick glance at recent publications from another author he cites (Mozaffarian) got me this:

Considerable research supports cardiovascular benefits of consuming omega-3 PUFA, also known as (n-3) PUFA, from fish or fish oil.

Excessive skepticism is probably better than hype, but it will discourage many people from reading it. Plus the style is somewhere in between a reference book and a book that I’d read from start to end.

The CFTC is suing Intrade for apparently allowing U.S. residents to trade contracts on gold, unemployment rates and a few others that it had agreed to prevent U.S. residents from trading. The CFTC is apparently not commenting on whether Intrade’s political contracts violate any laws.

U.S. traders will need to close our accounts.

The email I got says

In the near future we’ll announce plans for a new exchange model that will allow legal participation from all jurisdictions – including the US.

(no statement about whether it will involve real money, which suggests that it won’t).

I had already been considering closing my account because of the hassle of figuring out my Intrade income for tax purposes.

Book review: The Willpower Instinct: How Self-Control Works, Why It Matters, and What You Can Do To Get More of It, by Kelly McGonigal.

This book starts out seeming to belabor ideas that seem obvious to me, but before too long it offers counterintuitive approaches that I ought to try.

The approach that I find hardest to reconcile with my intuition is that self-forgiveness over giving into temptations helps increase willpower, while feeling guilt or shame about having failed reduces willpower, so what seems like an incentive to avoid temptation is likely to reduce our ability to resist the temptation.

Another important but counterintuitive claim is that trying to suppress thoughts about a temptation (e.g. candy) makes it harder to resist the temptation. Whereas accepting that part of my mind wants candy (while remembering that I ought to follow a rule of eating less candy) makes it easier for me to resist the candy.

A careless author could have failed to convince me this is plausible. But McGonigal points out the similarities to trying to follow an instruction to not think of white bears – how could I suppress thoughts of white bears of some part of my mind didn’t activate a concept of white bears to monitor my compliance with the instruction? Can I think of candy without attracting the attention of the candy-liking parts of my mind?

As a result of reading the book, I have started paying attention to whether the pleasure I feel when playing computer games lives up to the anticipation I feel when I’m tempted to start one. I haven’t been surprised to observe that I sometimes feel no pleasure after starting the game. But it now seems easier to remember those times of pleasureless playing, and I expect that is weakening my anticipation or rewards.

Book review: The Signal and the Noise: Why So Many Predictions Fail-but Some Don’t by Nate Silver.

This is a well-written book about the challenges associated with making predictions. But nearly all the ideas in it were ones I was already familiar with.

I agree with nearly everything the book says. But I’ll mention two small disagreements.

He claims that 0 and 100 percent are probabilities. Many Bayesians dispute that. He has a logically consistent interpretation and doesn’t claim it’s ever sane to believe something with probability 0 or 100 percent, so I’m not sure the difference matters, but rejecting the idea that those can represent probabilities seems at least like a simpler way of avoiding mistakes.

When pointing out the weak correlation between calorie consumption and obesity, he says he doesn’t know of an “obesity skeptics” community that would be comparable to the global warming skeptics. In fact there are people (e.g. Dave Asprey) who deny that excess calories cause obesity (with better tests than the global warming skeptics).

It would make sense to read this book instead of alternatives such as Moneyball and Tetlock’s Expert Political Judgment, but if you’ve been reading books in this area already this one won’t seem important.

The recent Quantified Self conference was my first QS event, and was one of the best conferences I’ve attended.

I had been hesitant to attend QS events because they seem to attract large crowds, where I usually find it harder to be social. But this conference was arranged so that there was no real center where crowds gathered, so people spread out into smaller groups where I found it easier to join a conversation.

Kevin Kelly called this “The Measured Century”. People still underestimate how much improved measurement contributed to the industrial revolution. If we’re seeing a much larger improvement in measurement, people will likely underestimate the importance of that for quite a while.

The conference had many more ideas than I had time to hear, and I still need to evaluate many of he ideas I did hear. Here are a few:

I finally got around to looking at DIYgenomics, and have signed up for their empathy study (not too impressive so far) and their microbiome study (probiotics) which is waiting for more people before starting.

LUMOback looks like it will be an easy way to improve my posture. The initial version will require a device I don’t have, but it sounds like they’ll have an Android version sometime next year.

Steve Fowkes’ talk about urine pH testing sounds worth trying out.