I recently tried larger-than-normal methylfolate supplements. I had known that my genes caused problems with processing folate (MTHFR T/T), but hadn’t noticed any effects from supplementing at 800mcg/day.
Due to a report that several milligrams/day helped with depression, I changed from 400mcg/day to 2mg/day. I felt like my mind started working better within hours (although I haven’t seen much change in behavior). I saw a clear and large improvement in my heart rate variability starting after one day.
I’ve experimented for 5 weeks randomly altering my dose from 1 to 3 mg/day. On the week when I switched from 3 to 1 mg, my mood slowly got worse. I felt much better withing hours of switching back to 3 mg. I haven’t noticed any clear difference between 2 and 3mg.
It was nice to meet you at the EA Summit, Peter.
Is there an easy way to check for folate processing problems with 23andMe data?
No easy way that I see. See here for how to find the 23andme data and here for some help interpreting it. I originally got the info about my MTHFR genes from WellnessFX, which did a moderately good job of explaining it.